Rejuran’s 4 Variants: What’s the Difference? — A Complete Comparison of Healer, i, HB+, and S

"I looked into getting Rejuran, but there are Healer, i, HB, S... why are there so many types?" It’s a question we hear several times a day in the consultation room. Some people even ask, "Aren’t they all just the same Rejuran?"

The answer is: "The core ingredient is the same, but the purpose of use is different." All four are based on the same regenerative ingredient, PN (polynucleotide), but they are designed with different viscosities and formulations to be optimized for different areas and concerns. Today, we’ll break down how they are recommended by criteria at Diorae Clinic near Gangnam Station.

First, how PN changes the skin

The key to Rejuran is PN, extracted and purified from salmon DNA. It is known as a biocompatible substance with very low likelihood of triggering an immune response because its base composition is highly similar to that of human DNA.

When injected into the dermis, PN stimulates the adenosine A2A receptor, increasing fibroblast (collagen-producing cells) proliferation and collagen and elastin synthesis. A 2024 study by Lampridou et al. published in Journal of Cosmetic Dermatology also confirmed that fibroblast activity and collagen synthesis increased significantly after PN exposure.

In other words, Rejuran is not a treatment that "fills something in," but one that awakens the skin’s natural ability to recover. Its mechanism is fundamentally different from fillers or Botox.

The four Rejuran types at a glance

They may look similar in the table, but when you break them down one by one below, the selection criteria become quite clear.

① Rejuran Healer — the original, the oldest, and the most versatile

This is the original product, launched first among the four and used the most. Since it is a single-ingredient PN formula with no added ingredients, it can be seen as the formulation most focused on regenerative effects.

When injected evenly across the entire face, it can bring broad changes such as increased skin thickness, improved elasticity, reduction of fine lines, smaller pores, and better oil-water balance. In a randomized controlled clinical trial involving 72 participants, the PN injection group showed significantly higher skin elasticity and collagen density than the HA filler group, and surface roughness and wrinkle depth also improved.

Suitable for:

• Those who need overall facial elasticity and regeneration
• Those concerned about fine lines, pores, and dryness at the same time
• Those who want to experience Rejuran’s unique regenerative effect in its purest form

② Rejuran i — a diluted formulation for the eye area

The skin around the eyes is about 40% thinner than other areas of the face and has a dense vascular network. If regular Rejuran is injected as-is, this area is prone to long-lasting wheals or bruising.

Rejuran i was made as a lower-viscosity, thinner formulation to address this issue. It contains the same PN, but is designed to spread smoothly even in thin skin around the eyes, with almost no risk of showing through under the skin or forming clumps or nodules.

In a study of 218 Asian participants, crow’s feet were reported to have decreased by about 61.4% 12 weeks after PN injection, with side effects limited to mild swelling, bruising, and pain.

Suitable for:

• Those concerned about fine lines around the eyes or dark circles
• Those worried that filler may show through because the skin under the eyes is thin
• Those whose eye corners look droopy due to reduced elasticity

③ Rejuran HB+ — a version that directly addresses the pain issue

Even knowing Rejuran is good, the biggest reason people hesitate to get it is pain. HB+ was created with this in mind.

Hyaluronic acid (HA) and the local anesthetic lidocaine are added to the existing PN. In a clinical trial of 53 participants conducted at Seoul National University Bundang Hospital, pain immediately after the procedure was confirmed to have decreased by about 53% compared with regular Rejuran.

Because HA is added, HB+ also offers the regenerative effect of PN along with the moisture and dewy glow effect felt immediately after injection.

Suitable for:

• Those who are concerned about Rejuran’s pain
• Those who want both regeneration and hydration
• Those who want dewy, radiant skin
• Those trying Rejuran for the first time

④ Rejuran S — a high-viscosity version made specifically for scars

"S" stands for Scar. It is the highest-viscosity gel-type product among the four and is designed for depressed acne scars or post-traumatic depressed scars.

Thanks to its high viscosity, it acts as a 3D physical scaffold at the base of the scar immediately after injection. It physically supports the surrounding tissue to lift the depressed area right after treatment, and at the same time, as it gradually breaks down, it stimulates fibroblasts to produce new collagen.

It is especially synergistic when combined with subcision or fractional laser treatments.

Suitable for:

• Those concerned about acne scars (boxcar, rolling, ice pick types)
• Those who want to improve post-traumatic depressed scars
• Those who want to enhance the effect of existing scar treatments

So, which Rejuran should I choose?

I want to improve the overall condition of my face → Rejuran Healer or HB+

I want focused care for the eye area only → Rejuran i

I want to avoid pain but still want a dewy glow effect → Rejuran HB+

I want to improve depressed scars → Rejuran S

You do not necessarily have to choose only one type. In practice, it is more common to combine different Rejuran types by area.

Combinations that create strong synergy with Rejuran

• Rejuran + Botox: The regenerative effect of PN and the wrinkle-relaxing effect of Botox combine to maximize improvement in fine lines
• Rejuran S + subcision / fractional laser: Particularly effective for depressed scars by releasing adhesions beneath the scar while inducing regeneration at the same time
• Rejuran + Thermage / Ulthera: Rejuran handles dermal regeneration, while radiofrequency and ultrasound simultaneously drive collagen contraction and lifting

What foreign patients in Gangnam often ask when choosing a Rejuran type

Q. I’m staying in Korea for a short time. Can I get Rejuran Healer and HB+ on the same day in different areas?

Yes. It is actually common to combine them in the same visit, using Healer for the whole face and HB+ for areas that are especially sensitive or less tolerant of pain. However, they are not mixed and used in a single syringe; instead, they are injected separately by area, and the final combination is decided after directly examining the skin condition.

Q. Can I get Rejuran i for the eye area and Sofwave for full-face lifting on the same day?

Rejuran i is an injectable treatment that helps regenerate the skin itself around the eyes, while Sofwave is an ultrasound lifting device that operates on a completely different principle, targeting shallower layers via the SIFI method. Since the treatment areas and depths do not overlap, there are cases where both are done on the same day, but there is currently no clinical data directly comparing the effects of receiving both treatments together, so the decision is made through consultation based on individual skin condition.

Q. I heard Rejuran S is good for scars, but how is it different from Rejuto?

Rejuran S uses PN to physically support the tissue under the scar while inducing regeneration, whereas Rejuto is classified as a biostimulator that stimulates collagen production, so its category and mechanism of action are entirely different. Rejuran S is the more specialized option for scar treatment, while Rejuto is used more often for overall skin elasticity and volume improvement. Whether the two products should be used together in the same area is decided individually after assessing scar depth and skin condition.

Frequently Asked Questions (Q&A)

Q1. Can I get Rejuran if I have a salmon allergy?

Rejuran’s PN is a highly purified ingredient extracted from salmon DNA, with nearly all allergy-causing proteins removed. However, if you have had a severe allergic reaction to salmon in the past, be sure to inform the medical staff before the procedure.

Q2. How long does the wheal-like bump after treatment last?

Healer and HB+ usually settle within 1~2 days, and i also subsides within 1~2 days. S has higher viscosity, so it may take 3~7 days.

Q3. How many sessions are needed to see results?

Even one session can often lead to noticeable skin texture changes after about 2 weeks, but for the best results, 3 or more sessions at 2~4 week intervals are recommended.

Q4. Is HB+ less effective than Healer?

Because the concentration of the key regenerative ingredient PN is the same, the regenerative effect itself is almost identical. HB+ simply adds HA (hydration) and lidocaine (pain relief).

Q5. Will acne scars disappear completely if I only get S?

If the scar is deep, it is difficult to expect complete improvement with a single treatment alone. The best results are obtained when combined with other scar treatments such as subcision and fractional laser.

Q6. Can all four types be injected at the same time?

It is possible to combine different Rejuran types by area on the same day. We recommend deciding the combination that suits each person through consultation.

Closing

The four Rejuran types ultimately differ in how the same ingredient, PN, is diluted and formulated for different purposes. What matters is choosing the right product for your skin condition and concerns, and the precise injection technique of an experienced medical professional.

If you’re wondering which Rejuran is right for you, feel free to book a consultation. After examining your skin directly, we will suggest the most suitable treatment plan.

References

1. Lampridou M, et al. Increased fibroblast activity and collagen synthesis after PN exposure. J Cosmet Dermatol. 2024;23(6).
2. Rho NK, et al. A Survey on the Cosmetic Use of Injectable Polynucleotide Products Among Practitioners. J Cosmet Dermatol. 2024;23(6):1234-1242.
3. Lee KWA, et al. Polynucleotides in aesthetic medicine: a review of current practices. Int J Mol Sci. 2024;25(15):8224.
4. PDRN review article: In a Rejuran study with 218 participants, a 61.4% reduction in crow’s feet was reported after 12 weeks. Appl Sci. 2025;15(19):10437.
5. Pak CS, et al. A phase III, randomized, double-blind clinical trial: polynucleotide filler vs HA filler in crow's feet. J Korean Med Sci. 2014;29(S3):S201.